Abstract
Summary
1. A simple, easily readable method for the clinical determination of streptomycin in body fluids has been described requiring a minimum amount of test fluid,
2. Klebsiella pneumoniae No. 41 which grows luxuriantly in simple media and is readily inhibited by streptomycin was adopted as test organism.
3. The assay was made more sensitive by utilizing relatively deficient media which made the test organisms more susceptible to the action of streptomycin.
4. It is possible, because Klebsiella pneumoniae No. 41 is insensitive to penicillin, to perform streptomycin level determinations in patients who are receiving streptomycin and penicillin treatment concomitantly.
5. By the use of this method it has been noted that streptomycin is retained in the blood in effective therapeutic amounts for relatively longer periods of time, thereby permitting more convenient spacing of injections. The clinical application of these studies will be made the subject of a subsequent report.
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