Abstract
Summary
Hypophysectomy of adult female rats within 2 hours after the beginning of proestrus prevents ovulation from occurring within a 46-hour postoperative interval. Sham hypophysectomy does not prevent ovulation as shown by the presence of partially developed corpora lutea and tubal ova. It is concluded that a hypophyseal hormone (LH) is required for ovulation and luteinization in the rat and that the quantity of hormone needed to produce ovulation and luteinization is secreted subsequent to early proestrus.
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