Abstract
Summary
1. l+ glumatic acid, when infused at a rate of 10 mg/kg per minute in dogs induced vomiting on an average when 136 mg/kg had been administered.
2. Atropine, d-desoxyephedrine, tridione, or pyridoxine with thiamine had no significant effect in delaying vomiting.
3. When nembutal, 2 mg/kg was given intravenously 10 minutes before the glutamic-acid infusion, vomiting was not induced until an average of 241 mg/kg had been given, an 84% improvement in tolerance.
4. Epinephrine, infused with glutamic acid in a concentration of 2 μg/kg/min delayed vomiting until an average of 198 mg/kg had been infused, a 45% tolerance increase.
5. Tolerance to glutamic acid increased if infusions were repeated within 4 to 6 days.
6. The possible applications of these findings to the clinical use of protein hydrolysates are briefly discussed.
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