Abstract
Summary
The distribution of alkaline phosphatase was studied in the uteri of untreated ovariectomized mice and in castrates injected with 3 steroid sex hormones. In the untreated castrate large amounts of the enzyme are present in the longitudinal muscle and smaller amounts are found in the circular muscle. Occasional small amounts are also present in the uterine glands and epithelium. Injection of estrogen is followed by marked increase of phosphatase in the uterine glands and epithelium and in the circular muscle. Progesterone and androgen do not have this effect. Progesterone given concurrently with estrogen does not alter the enzyme response to estrogen.
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