Abstract
Summary
Marked age variation in the susceptibility of wild Norway rats to acute poisoning with a-naphthyl thiourea has been found, with suckling rats about 7 times as rehistant as adults. This reGstance was found to decrease with increasing body weight, levelling off for adults at an LDSo between 6 and 8 mg/kg body weight. The difference found between adult males and females was within the limits of error and is therefore not considered significant.
Adult animals of other species also varied Markedly in susceptibility to acute ANTU poisoning. Korway rats, dogs and mice were killed by amounts less than a hundred milligrams per kilogram. Alexandrine rats, guinea pigs, and cats required several hundred milligrams, while chickens and monkeys survived doses of several grams per kilogram body weight. Large amounts of pulmonary edema were found only in Norway rats, dogs, mice and cats.
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