Abstract
Summary
A method of testing the sensitivity of dysentery bacilli to the bacteriostatic action of sodium sulfadiazine is described. The method involves the use of a medium which is essentially free of sulfonamide inhibitors. Of 219 strains tested, 202 were found to be susceptible to the drug while 17 strains were found to be resistant. Among the susceptible strains were representatives of each of the well established varieties of Shigella. The resistant strains included representatives of Sh. Paradysenteriae (Flexner types W, Z and VZ) and Sh. Sonnet, Many of the resistant strains were isolated from patients who failed to respond to treatment with sulfonamides, The results serve to emphasize a potential difficulty in the chemotherapy of dysentery.
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