Abstract
Summary
1. The average respiratory rate, tidal air, and minute volume were measured in 39 unanesthetized, untrained, young monkeys (Macaca mulatto,) with an average weight of 2.63 kg (a- = ± 0.41 kg, e= ± 0.07 kg).
2. Expressing the tidal air or minute volume in terms of body weight in kilograms, body surface area in square meters, or body weight in kilograms raised to the 0.73 power resulted in practically identical coefficients of variation.
3. The mean values observed were as follows:
a. Respiratory rate: 37 per minute (a=± 6.6; e= ± 1.1).
b. Tidal air: 10.1 cc per kg (<r = ± 2.8 cc; e = ±0.5 cc) or 119.6 cc per square meter (a = ± 33.4 cc; ε = ± 5.3 cc).
c. Minute Volume: 383 cc per kg (o- = ± 129 cc; ε = ± 21 cc) or 4532 cc per square meter (o- = ± 1554 cc: e = ± 248.8 cc) or 498.7 cc per kg body weight raised to the 0.73 power (a- = ± 173.2 cc; ε = ±27.7 cc).
4. No correlation was found between the animals' pulse rate (mean = 215 per minute) (a = ±27; t = ±4.5), which was intended as an index of excitability, and any of the respiratory data.
5. The respiratory rate, tidal air. and minute volume were significantly inhibited in monkeys exposed to a phosgene concentration of 1.38 mg/1.
6.a. The mean heat production determined by the indirect method in 4 unanesthetized, untrained, tracheotomized macaques with an average weight of 3.49 kg was 85.76 Cals/ kg/24 hrs and 1137.29 Cals/sq.M/24 hrs— approximately 180% of the basal values reported in the literature.
b. The mean heat production of the same macaques sedated with 10 mg/kg of nembutal intraperitoneally was 92.77 Cals/ kg/24 hrs and 1202.08 Cals/sq.M/24 hrs.
7. The average coefficient of oxygen utilization in these 4 monkeys was 2.10% for the non-sedated and 2.40% for the nembutalized macaques.
Get full access to this article
View all access options for this article.