Transplantability of Induced Granulosa Cell Tumors and of Luteoma in Mice. Secondary Effects of These Growths. ∗

Abstract

Summary

Eleven ovarian tumors, induced by X-rays have been transmitted in successive passages. Eight were of the granulosa cell types, 2 were luteomas and one was a tubular adenoma. Histological changes indicate that cells of Strain III secrete estrogens. Mice bearing tumors of this strain also have a cavernous dilatation of the sinusoids of liver, spleen and adrenals. In mice bearing large luteoma of Strain IX there is profound atrophy of the adrenal cortex.