Abstract
Summary
1. By the use of various dosages of thiamine, magnesium sulphate, decholin and aminophylline, it was shown that lower doses are either ineffective or produce prolonged circulation times. 2. Logarithmic curves express this relationship of circulation time to dosage. These vary from person to person. 3. Beyond a certain dose, varying in different individuals, further increase in dosage causes no appreciable decrease in circulation time. This may be called the optimal or asymptotic dose, and the time the shortest or “true” circulation time. 4. Increasing the volumes containing the same doses of thiamine to 5 cc or more, shorten the circulation times markedly enough to affect clinical measurements.
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