Effect of Protein Depletion on Plasma Proteins in the Dog Measured by Electrophoretic Analysis

Abstract

Summary and Conclusions

Electro-phoretic analyses of plasma showed that protein depletion in dogs resulted in marked decrease in circulating albumin, and slight decrease in γ globulin. In contrast to these decreases the a globulin content remained essentially unchanged or increased. The α globulins, however, always increased in concentration, which was in part due to the accompanying fall of plasma volume. The Howe method for the determination of albumin: globulin ratios resulted in higher ratios than those obtained by electrophoretic analyses, because of the contamination of globulins in the “albumin” fraction.