Abstract
At the May meeting of this Society, one of us (J.) reported that by the use of magnesium, certain toxic effects of physostigmin can be completely overcome. In our present communication we wish to bring out the fact that the antagonism between physostigmin and magnesium is mutual, at least to a certain extent. We wish to show an experiment which demonstrates that physostigmin can overcome certain toxic effects of magnesium and thus save the life of a poisoned animal.
Both these rabbits (A and B) received at about the same time 1.2 gram of magnesium sulphate per kilo of body weight. The injections were given intramuscularly in the lumbar region. Rabbit B received in addition one milligram of eserin, also intramuscularly. Rabbit A is already dead. Rabbit B is still alive; although anesthetic and limp, it breathes regularly and apparently is in no danger of death. 1
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