Abstract
Summary
In 4 instances of fatal, so-called renal crush syndrome in man, study at necropsy disclosed glomerular ischemia or oligemia; enlargement of the juxta-glomerular apparatus with increased granularity of the cells, hyperplasia and hypertrophy of the afibrillar (granular and non-granular) cells of the media of the pre-glomerular arterioles. In 2 of the 4 cases, intimal granulomata and parietal thrombi were found in the interlobular veins. Since similar changes are found in ischemic (Goldblatt) kidneys, in which the author postulated an endocrino-logic role for the affected cells, consisting of the liberation of a vasopressor substance, it is suggested that similar liberation of a vasopressor substance occurs in the anuric crush syndrome, causing arteriolar spasm at the vascular pole of the glomerular tufts.
Get full access to this article
View all access options for this article.