Acute and Subacute Toxicity of Pure Gitrinin

Abstract

Conclusions

The lower toxicity values reported by Robinson, as compared with those reported by Timonin and Routt and those reported here, may be due to a low rate of absorption fo citrinin from a suspension in gum solution.

Citrinin in solution is rapidly absorbed, regardless of the mode of administration, as shown by the toxicity data.

The production of tissue changes and the fact that citrinin may result in delayed deaths, up to fourteen days, would make a statement regardless an LD₅₀ dose misleading.