Abstract
Summary
There is a species variation in the local reaction to intradermal injections of histamine. The dog, goat, and man show a marked skin whealing, but no such response is obtainable in the guinea pig, rabbit, or cat.
The diameter of the skin wheal produced by intradermal injection is a function of the concentration of histamine used, the threshold being 0.001%. In the presence of an extraneous histamine-like substance, this relationship still exists, but the threshold of histamine sensitivity is elevated to 0.01%.
A practical application to the field of experimental dermatology is suggested involving the proper selection of test animals and the use of histamine as a standardizing agent.
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