Abstract
Summary
We have studied in cats the effect of an atrophy of the soleus and tibialis anticus, caused by an arthritis of the tibio-tarsal joint, on some aspects of the synaptic transmission in those muscles.
1. The third stage of the neuromuscular transmission is different in the normal and arthritic muscles. Section A, fig. 1 and 2.
2. The atrophic muscle is more resistant to curarization. Section C, fig. 3.
3. Prostigmine, with the same dosage and frequency of stimulation, produces less potentiation and more depression in the arthritic than in normal muscles.
4. The synaptic behavior of the arthritic muscle is similar to the behavior of the teno-tomized, immobilized, and fatigued (4th stage) muscles. The possible significance of such similarity is discussed.
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