The Use of Regenerating Liver as a Method of Assay. ∗

Abstract

Conclusion

1. The time at which mitosis in regenerating liver reaches a maximum varies with the age of the animal. 2. P³² updake by regenerating liver, 3 hours after intravenous administration administration of labeled Na₂HPO₄, varies with time after partial hepatectomy. This variation may be related to changes in liver volume or to mitotic activity or both. 3. P³² retention 27 hours after subcutaneous administration of labeled Na₂HPO₄, shows little variation with time after operation. 4. The mitotic rate provides a useful index which may be used in assaying the effect of various agents on the reproduction of liver cells.