Abstract
Summary
Previous experimental infection (or inoculation without infection) with a strain of homologous serum jaundice obtained in the Middle East failed to protect 5 human volunteers against subsequent experimental infection induced 6 months later with a strain of infectious hepatitis also obtained in the Middle East.
These results are in contrast to those found by Oliphant, who has described immunity in human subjects convalescent 6-19 months from homologous serum jaundice, when inoculated with serum from acute cases of infectious hepatitis.
Using a strain of the naturally occurring disease, infectious hepatitis, no appreciable difference in incubation period was observed in experimental cases when equal amounts of the same infectious agent were inoculated parenterally or fed. Incubation periods ranged from 20-34 (average 24) days.
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