Abstract
Summary
Rats of an inbred line, which were 100% susceptible to a reticulum cell type of lymphosarcoma arising spontaneously in the same strain, could, in an appreciable percentage of cases, be rendered resistant to the same tumor. The method consisted of implanting tumor grafts which were previously attenuated with specific doses of X-rays, In most cases the resistant state followed inoculation without the appearance of any visible tumor. In certain cases a tumor did appear but regressed after having reached a certain size. These likewise became immune. Hence this procedure eventually resulted in immunity to an autogenous tumor. Out of 58 control rats, only one spontaneous regression was observed. This rat likewise proved to be refractory to further viable tumor grafts of the same type.
The results of these experiments give evidence, apparently for the first time, that it is possible to render animals of a pure line immune against an autogenous tumor.
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