Abstract
Summary
The effect of sulfamerazine on pulmonary infections in mice, hamsters, rats, and cotton rats, and on yolk sac infections in chick embryos with the agents of murine and feline pneumonitis was studied. The drug inhibited the action of the mouse virus in all the species tested and was effective in very small doses, 0.0025 mg per gram of body weight in mice and somewhat larger doses, 0.1 mg/g, in hamsters. With the agent of feline pneumonitis, large doses of sulfamerazine, near the toxic limits, produced moderate inhibition of the lung lesions in hamsters and white rats, slight inhibition in cotton rats, and no effect in mice or chick embryos.
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