Abstract
Summary
Polysaccharides prepared from Ascaris lumbricoides and hydatid fluid, as well as liver glycogen, produce a sharp reduction in blood histamine in the unanesthetized rabbit or in those under Dial + ether anesthesia, urethane and chloralose anesthesia. Concomitantly, platelets almost disappear from circulating blood while the leucocytes are reduced only in the unanesthetized rabbit or in those under Dial + ether anesthesia. Under chloralose or urethane anesthesia, there was rather a leucocytosis after the injection of glycogen. Thus the conclusion was drawn that histamine is bound to platelets in rabbit blood. Glycogen has a definite inhibitory effect upon the course of anaphylactic shock, explained by the fact that glycogen disperses the blood elements, without a preferential allocation of those in the shock organ, while anaphylactic shock in the rabbit occurs as a consequence of the clumping of leucocytes and platelets in the lung capillaries and small vessels, which become a filter for agglutinated blood elements.
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