Abstract
Summary
Using 3 species of fungi, the fungistatic and fungicidal actions of clavacin were investigated. The presence of 0.02%, and with some samples 0.01%, of clavacin in the culture medium completely inhibited the growth of Trichophyton gypseum. A concentration of 0.001% of clavacin caused partial inhibition while 0.0001% caused no detectable effect. In contrast, the presence of 0.04% of clavacin had but a slight inhibitory effect on Monilia albicans and Oidium asteroides.
A 1% solution of clavacin was fungicidal for T. gypseum in 15 minutes, the shortest exposure time employed, M. albicans in 30 minutes, and O. asteroides in 15 minutes to 1 hour. Solutions containing 0.5% clavacin were fungicidal for T. gypseum in 15 to 45 minutes, to M. albicans in 45 minutes to 3 hours, and for O. asteroides in 1 to 3 hours. The 0.1% solutions killed T. gypseum in 2 to 5 hours but failed to be fungicidal for the other two organisms even after 24 hours.
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