Abstract
Summary
A study of the resistance to the intraperitoneal injection of Type I pneumococci of 39 rats showing pantothenic acid deficiency in contrast to 36 controls fed pantothenic acid failed to reveal a significant change in the susceptibility of the experimental group. Similarly, no marked change in susceptibility was observed in 175 mice showing pantothenic acid deficiency in contrast to the survival percentage of 141 controls receiving the vitamin (normal animals). However, the difference is great enough to warrant the conclusion that acute pantothenic acid deficiency in mice may slightly increase the resistance to Type I pneumococcus. Certainly the results give no indication of decreased resistance to this organism in pantothenic acid deficiency.
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