Abstract
Summary
Thiobarbituric acid is a specific reagent for the determination of sulfadiazine (free or acetylated) among the sulfonamides because it reacts with the aminopyrimidine moiety. In most urines, however, the acetylated fraction which appears following the ingestion of sulfadiazine does not react unless the urine first be aged or be treated with a reducing agent. This suggests that the pyrimidine ring has been oxidized. Acetylsulfadiazine taken by mouth, when subsequently excreted in the urine, does not experience this change.
Get full access to this article
View all access options for this article.