Occurrence of Stainable Lipoid Material in Renal Epithelium of Animals Falling in Different Age Segments. *

Abstract

Conclusions

1. Microchemically demonstrable lipoid material is not present in the epithelium of the cells of the proximal convolution of the nephron in puppies varying in age from 6 weeks to 4 months. Young adult animals under 1 year of age have rarely shown such material as fine dust-like granules. 2. As the dog ages, stainable lipoid makes its appearance in the cells of the proximal convoluted segment and increases in amount in this location as the animal advances in years. 3. In nephritic senile animals that have repaired the epithelial injury in the proximal segment by the formation of an atypical, flattened order of epithelial structure stainable lipoid material cannot be demonstrated by the use of a similar technic which does demonstrate its presence in cells of a normal order in this location. 4. Such variations in the occurrence of stainable lipoid material are not due to qualitative variations in the food intake. 5. Intracellular chemical manipulations would appear to become so modified by the factor of age as to influence the amount and distribution of stainable lipoid material in the cells of the proximal convolution of the nephron.