Effect of Mapharsen on Bromsulphalein Retention in Normal Dogs. *

Abstract

Summary

Fifty-nine per cent of 17 normal dogs developed an abnormal liver function after a single injection of 60 mg of Mapharsen. The dye retention occurred irrespective of dosage over a range of 2.7 to 9.1 mg/kg of body weight. Dogs showing hepatic dysfunction from an initial injection of Mapharsen, subsequently showed less dye retention or a complete return to normal on 2 subsequent injections. Dogs having a normal bromsulphalein retention after one injection of Mapharsen also showed a normal dye retention following two subsequent injections.