Relation of Adrenal Gland and Hypophysis to Blood Sugar Levels Following Administration of Alloxan. *

Abstract

Summary

An initial hyperglycemia did not appear in either adrenalectomized or hypophysectomized rats injected with alloxan. with the doses of alloxan used, hypoglycemic convulsions did not appear in any of 15 intact animals whereas convulsions occurred within 6 hr in all of 14 adrenalectomized and 9 of 10 hypophysectomized animals. In the absence of the adrenal medulla the reaction to alloxan was the same as in intact animals; removal of the adrenal cortex (regenerated cortex following adrenal enucleation) resulted in the same reaction as total adrenalectomy.