Influence of Protein and Thiamine Intake on Pathologic and Weight Changes Produced by Atabrine. *

Abstract

Summary

The hepatic damage resulting from continued atabrine administration was more severe in rats maintained on a low protein diet than in those on a high protein diet. On the other hand, the incidence and degree of myocardial damage were slightly greater in the rats fed the high protein diet. Thiamine deficiency had no effect upon the hepatic and myocardial damage produced by atabrine. The daily administration of atabrine to rats maintained on high and low protein rations resulted in a retardation of growth beyond that observed in their isocaloric controls which did not receive atabrine.