2(Naphthyl-(1')-Methyl)-Imidazoline Hydrochloride (Privine). * I. Potency in Modifying Cocaine Hydrochloride-Induced Convulsions

Abstract

Summary

1. Privine, on the basis of the method employed for comparison, is a less effective vasoconstrictor than epinephrine. 2. The LD₅₀ of Privine for guinea pigs is intermediate between 1 cc of 1:250 (4 mg) and 1 cc of 1:100 (10 mg) per kilogram. 3. Actively growing guinea pigs of less than 300 g are more sensitive to a given toxic dose of cocaine in g per kg than are mature or less actively growing guinea pigs of more than 300 g. 4. The toxicity, after subcutaneous injection, of a dose of cocaine in g per kg may be decreased by decreasing the concentration of the solution used for injection; this has been previously reported by other investigators.