Effect of Tobacco Virus,Some Decomposition Products of Nucleoproteins,and Related Compounds on Acetylcholine Synthesis. *

Abstract

Summary and Conclusions

1. The effect of tobacco virus, some of the decomposition products of nucleoproteins, and some related substances on the synthesis of acetylcholine was investigated. 2. Tobacco virus, methylxanthines, adenylic acid, and urea increased the synthesis of acetylcholine. 3. The synthesis was not modified by thiourea. 4. Piperidine increased the synthesis in lower concentrations and decreased it in higher ones. 5. Methylguanidine and uracil did not modify the synthesis in low concentrations and decreased it in higher ones. 6. The synthesis of acetylcholine was decreased in the presence of nucleic acid, inosinic acid, adenine, guanine, xanthine, adenosine, thiouracil, uric acid, pyridine, 2-methyl-5-ethoxymethyl-6-amino pyrimidine, 4-methyl-5-β-hydroxyethyl thiazole, pyrol, and alloxan.