Abstract
Summary
Heparin does not appear to be specific antitryptic substance since it prevents neither the fall in blood pressure produced by trypsin in the dog nor the proteolytic activity of trypsin on a hemoglobin substrate. However, heparin does protect guinea pigs against the lethal effects of intravenously injected trypsin.
The observation that fastusol, like heparin, protects rats against the lethal effects of trypsin is compatible with the notion that such a protective action on the part of heparin is related to its anticoagulant properties.
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