Abstract
Summary
The administration of large amounts of fresh wheat germ which was vacuum packed and sealed reduced the creatinuria in 3 patients with dermatomyositis. Other samples of wheat germ, stored in bulk, were ineffective. In another subject with progressive muscular dystrophy the creatinuria was diminished in one experiment and unaffected during a second period of wheat germ feeding. Wheat germ incubated in vitro with normal human gastric juice had more effect on creatinuria than had the fresh product. Prolonged extraction with ethyl ether reduced but did not remove completely the factor or factors in wheat germ that lower the output of creatine. On the other hand, wheat germ defatted by extraction with ethylene dichloride was entirely without effect on the creatinuria. Of various vitamins and other substances investigated only soy bean lecithin reduced the creatinuria.
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