Abstract
Summary
In the thyroprived cow with pronounced myxedema no mammary development was obtained by diethylstilbestrol or thyroprotein administration. Negative results were also obtained with the simultaneous administration of these two substances as long as myxedema persisted. Substantial mammary development and lactation resulted from diethylstilbestrol administration following recovery from myxedematous symptoms by thyroprotein therapy. It is suggested that the failure of mammary development in the myxedematous animal is due to some phase of the myxedema and that the response obtained following thyroid therapy is not due to a synergistic action of thyroxine and diethylstilbestrol.
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