Effect of Feeding Dried Milk on Production of Liver Cancer by p-Dimethylaminoazobenzene.

Abstract

Summary

1. The therapeutic action of dried whole milk upon liver cirrhosis and cancer has been investigated. The liver changes were induced in rats by feeding unpolished rice and p-dimethylaminoazobenzene. 2. The production of liver cancer in rats fed p-dimethyl-aminoazobenzene was partially inhibited by the daily ingestion of dried whole milk (50% protection at 200 days). 3. Liver cirrhosis produced by p-dimethylaminoazobenzene has been treated successfully by a rice diet containing 15% dried whole milk. (Based on previous evidence of the high incidence of liver cirrhosis in rats produced by p-dimethyl-aminoazobenzene-rice diet.¹¹). 4. Once ade-nomatous hyperplasia of bile ducts, cholan-gioma, or hepatoma had been established in the livers, these benign and malignant tumors could not be destroyed by ingestion of the rice-milk diet.