Abstract
Summary
Stilbestrol is about 100 times as active as estrone in causing the stimulation and release of adrenotropic and gonadotropic factors from the pituitaries of intact mature male rats. In castrated animals it is only about twice as active as estrone. Unlike estrone, the pituitary responses to stilbestrol are not influenced by the presence of the testes or the administration of progesterone, both of which depress the rate of inactivation of estrone as well as its pituitary stimulating activity. It would appear that the mechanism of stil-bestrol's action upon the pituitary differs from that of the naturally-occurring estrogens.
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