Abstract
Summary
Allantoic fluids infected with influenza A or B virus contain 3 antigenic fractions as measured by complement fixation technic: 1. sedimentable at relatively low speeds and directly linked with virus activity (600 S); 2. sedimentable at 90,000 g (30 S) possibly identical with the antigen observed in mouse lungs by Lennette and Horsfall;17 3. non-sedimentable at 90,000 g upon repeated centrifugation or in the presence of a sucrose density gradient (<30 S). The serological activity of fraction 2 and 3 appears to be based on one antigen, while the activity of fraction 1 is mainly due to another antigen distinct from fractions 2 and 3, as shown by serum absorption technic. The 30 S components of 2 strains of influenza A virus were found indistinguishable by serum absorption technic while the 600 S components revealed strain-specificity in addition to antigenic activity common to both strains.
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