Abstract
Summary
The increase in plasma fibrinogen levels in rats receiving atabrine has been correlated with the presence and degree of necrosis in the liver.
The maintenance of a blood level of about 5 γ per cc in 120 g rats was sufficient to induce gross liver damage after 5 weeks, irrespective of the number of doses given.
When dosed on a mg per kg basis, older rats appeared to have a decreased tolerance to atabrine poisoning. Evidence has been presented to show that the decrease in the ratio of liver weight to body weight with age may account for the earlier onset of liver damage in older rats.
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