Abstract
Summary
The β3-diethylaminoethyl esters of some substituted α-thienylaeetic and α-thienylglycolic acids have been investigated in the experimental animal and found to possess important antispasmodic properties.
The α-thienylglycolic acid esters are significantly more active than the former but also have greater effect on other cholinergically controlled structures, thus resembling atropine more than do the acetates. The antispasmodic activity of the cyelohexyl-α-thienylglycolate (No. 623) is comparable to that of atropine; the phenyl-α-thienylacetate (No. 606) appears to be somewhat more effective than β-diethylaminoethyl diphenyl acetate and equal to diethylaminoethyl fluorene-9-carboxylate. Compound No. 606 is relatively free from undesirable actions on other autonomic organs. Except for the phenyl-α-thienylglycolate (No. 600), toxicity of these substances is not unfavorable.
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