Effect of Dietary Hepatic Injury on Inactivation of Estrone

Abstract

Summary

Liver damage produced in rats by diets low in protein and high in fat was consistently reflected in the living animal by impairment in ability to inactivate estrone. The curative effect of large doses of yeast could be demonstrated.

Vitamin B-complex deficiency was usually accompanied by a similar but less constant hepatic impairment and without anatomical damage to the liver. There appeared to be a strain difference in susceptibility. A mixture of known vitamins was only partially effective in abolishing the effect of the diet, while yeast was distinctly and more consistently effective.