Effect of Thiamine Compounds on the Striated Muscle. ∗

Abstract

Summary

1. The effect of thiamine chloride, thiamine pyrophosphate, and acetyl-thiamine in inducing muscle contraction and the effect of the thiamine compounds on the muscle contraction induced by acetylcholine and potassium were investigated. 2. Thiamine compounds did not induce a contraction of the muscle in concentrations lower than 1.10^-2 M in a period of 3 minutes. 3. The thiamine compounds did not sensitize the muscle to acetylcholine. In higher concentrations the effect of acetylcholine in inducing muscle contraction was depressed. 4. The thiamine compounds significantly increased the effect of potassium in inducing muscle contraction.