Abstract
Summary
A simple method is presented which permits accurate comparative studies on the therapy of experimental renal obstruction from sulfadiazine. Under the conditions of this method, the results of experiments completed up to now, suggest that in fully developed renal obstruction from sulfadiazine, the generally recommended therapeutic measures—“forcing of fluids” with or without massive alkalinization—can be useless or even harmful, whereas, under identical conditions, solutions of neutral salts or of moderately alkalinizing salt mixtures are able to reopen the urinary pathways quickly and thus to save life.
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