Abstract
Summary
Except for sulfadiazine, nomosulfanilamide and its N1-methyl derivative were the most effective drugs in local treatment of experimental gas gangrene of the compounds tested. The acute toxicity of homosulfanilamide was less than that of its derivative. The chronic toxicity of homosulfanilamide in mice appeared to be no greater than that of sulfanilamide. These two compounds were not effective in the treatment of infections in mice with Strep. hemolyticus C203, H. influenza: 62/B, or Staph. aureus Smith, but they were bacteriostatic in vitro for staphylococci. Although infection with Cl. perfringens in mice is not strictly comparable with infection in man, these results indicate that homosulfanilamide may be worthy of a clinical trial in the local treatment of gas gangrene.
Get full access to this article
View all access options for this article.