Excretion in the Dog of Androgens and Estrogens in the Bile Following Injections of Androgens. ∗

Abstract

Summary and Conclusions

1. In bile fistula dogs a single injection of androsterone, testosterone, or methyl testosterone is followed by excretion of androgenic material in the bile. Excretion of small amounts of androgenic material may continue for 72 hours in spite of the fact that all of the androgen-containing bile is removed from the body. 2. The quantities excreted vary considerably in different experiments with either of the 3 compounds studied. 3. A single injection of androgen is frequently followed by excretion of estrogen in the bile. 4. In one instance androgen and estrogen were excreted in the bile following intraduodenal instillation of testosterone.