Abstract
Conclusions
(1) Thyroidectomy increases the resistance of the rat to anoxia; but only in fed animals. (2) Treatment with thyroxine decreases the resistance of the rat to anoxia. Since dinitrophenol, a metabolic stimulator without effect on thyroid deficiency, also decreases the resistance to a low oxygen pressure, the role of the thyroid in conditions of anoxia appears mediated through the effect of this gland on metabolism. (3) Animals given a 1% solution of thiourea in drinking water show a marked increase in resistance to anoxia probably as a consequence of the suppression of thyroid function due to this drug.
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