Abstract
Summary
When xanthopterin was added to cultures of A. aerogenes only small amounts of “folic acid” were synthesized by the organ-ism. Xanthopterin was without effect on the resulting turbidity of the cultures or on the amount of biotin produced. Several other purines, pyrimidines, and pterins were without effect on the growth of the organism or on the production of “folic acid” or of biotin. It is suggested that xanthopterin either may partially replace “folic acid” in metabolism or its structural similarity to an hypothetical intermediate in the microbiological synthesis of “folic acid” enables it to inhibit the synthesis or utilization of the intermediate.
Get full access to this article
View all access options for this article.