Action of Sulfonamides on Toxins of Agents of the Lymphogranuloma-Psittacosis Group

Abstract

Summary

Sulfamerazine has no effect on any of the endotoxins of the agents of the lymphogranuloma-psittacosis group and on the early deaths produced by such toxins, even when these are used in doses on the border line of lethality and are derived from lymphogranuloma venereum or mouse pneumonitis both of which infections are very susceptible to sulfonamide therapy. On the other h and, of the later deaths which occur following intravenous inoculation of the agents of mouse or feline pneumonitis, those occurring with mouse pneumonitis are entirely prevented with sulfamerazine while those with feline pneumonitis are not. These facts are in keeping with the previously postulated theory that these later deaths are due to infection while the earlier are due to toxemia.