Abstract
Summary
Quantities of Δ4-androstene-3-17-dione up to 40 times greater than the antifibromatogenic threshold of progesterone were not sufficient to prevent abdominal fibroids induced by alpha-estradiol. These quantities of androstenedione were also many times greater than the antifibromatogenic quantities of testosterone. The masculinizing action on the clitoris of the guinea pig was so pronounced as with testosterone. Quantities of cholestenone 10 times those of progesterone revealed no antifibromatogenic activity.
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