Abstract
Summary
Nineteen adult guinea pigs received three intraperitoneal injections of a 1/10 solution of paraldehyde, 10 cc per kilo, per week for 4 weeks. The average weight of the animals dropped from 499 to 469 g during the series of injections. These animals showed a tolerance to paraldehyde, following repeated administration of large doses of the drug, as indicated by a decrease in both the sleeping time and the length of hypnosis. The average time for the onset of sleep, for each series of injections, varied from about 85 to 120 seconds. The duration of sleep dropped from 95 to 31 minutes and the length of hypnosis dropped from 231 to 167 minutes.
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