Abstract
Summary
Orally administered sulfanilamide, sulfathiazole, sulfapyridine, sulfadiazine, sulfamerazine, and sulfaguanidine confer an equivalent but limited protective effect against the lethal action of intraperi-toneally-administered endotoxin of Salmonella typhimurium. Sulfanilamide has a similar effect on the endotoxin of Shigella paradysenteriæ Flexner. Sulfathiazole administered during the immunization of mice with Salmonella endotoxin appears not to interfere with the immunizing process, as determined by degree of resistance to the lethal action of the endotoxin. Reasons are advanced to support the view that these results apply to other sulfonamide drugs and to the endotoxins of gram-negative bacteria generally.
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