Abstract
Summary
Quantities of acetoxypregnenolone 10 to 20 times greater than the anti-fibromatogenic threshold of progesterone were unable to prevent the fibromatogenic and other toxic actions of estradiol. This gives new evidence in favor of the following 2 assumptions: first, that the ketonic oxygen at C3 is essential, or highly important for the antiestrogenic and antifibromatogenic activity of steroid hormones; and second, that the antifibromatogenic activity is often concomitant with the progestational one.
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