On the Mechanism of Fever Production with Inflammation. ∗

Abstract

Conclusion

In conclusion, the observations presented indicate that necrosin, the euglobulin fraction recovered from exudates and which is per se primarily responsible for the basic pattern of injury in inflammation, in turn induces, contrary to other protein fractions of exudates, an appreciable degree of fever when injected into the circulating blood of dogs. The absorption of this substance into the blood stream from the site of an acute injury offers a reasonable explanation for the probable factor largely responsible in the development of fever with inflammation.